I always have been against big science. I think it’s mostly a waste of money and all the history of science shows us that it never leads to the attempted goal. Jan Klein, the Czech-American immunologist, co-founded the modern science of immunogenetics. He is the author or co-author of over 560 scientific publications and of…
Everybody loves a good structure. Here’s one of the prototype foamy virus (PFV) integrase in complex with DNA ends. The integrase is the complex that binds the termini of viral DNA and catalyses its insertion into the host genome. Nasty piece of work, and incidentally one that has ‘nasty biophysical properties‘—at least the one from…
8
