We are are legion. Detection of differential splicing in cancer using gene expression arrays is the 1000th poster to be published at our open poster repository, https://posters.f1000.com/. Gene expression arrays have been a workhorse of biology for a number of years now, and there are vast sets of data. What happens when the same genes,…
Open source, open access, open posters even–but open science? Is that a step too far? The arguments over whether open data–publishing experimental results on the web, making datasets available, etc.–is a good thing, for science as a whole or individual careers, are likely to rage for quite a long time to come. That hasn’t stopped…
Back when the world was young I had a deep and abiding interest in the structure of components of the nuclear pore, especially those involved in getting messenger RNA out of the nucleus. The nuclear pore, you’ll recall, is a massive structure in the nuclear membrane of eukaryotes that keeps the DNA in and all…
What the bleep is a mastermind? Is it some kind of scheme involving aliens in collusion with their human puppets in the guise of businesspeople to take control of us all? I was talking with an old friend and colleague recently, and the question was implicit within the conversation. It soon became clear that the…
This week’s news includes news for the gray wolves of America, a controversial anti-aging pill, a stem cell suggestion for Japanese nuclear workers, bail for an imprisoned Indian doctor, and an interactive map of the brain.
Drug discovery isn’t getting any easier. Development of new pharmaceuticals–and improvement of existing ones–is a time-consuming and expensive process. Therefore, maximizing benefits–and reducing side effects–from compounds that already have known medicinal, or proto-medicinal, properties is an attractive option.
Today we have a meeting report from F1000 Member David Stephens, who is in the Department of Biochemistry at Bristol University. David went to the recent Biochemical Society/Wellcome Trust Focused Meeting on Cellular cytoskeletal motor proteins, held at the Wellcome Trust Genome Campus near Cambridge. For a fantastic summary of the state of the art…
You might remember an interview with Desmond Julian here at NS. We talked to Desmond because it fitted well with the launch of the British Heart Foundation’s Mending Broken Hearts campaign complete with talking fish. Last month we also published the results of our Best Places to Work (Postdocs) survey, in which University College London…
While Faculty of 1000 is the go-to website for all life science and medicine researchers, we don’t really cater for high school or college students. This is the nature of the enterprise: our F1000 Members select research papers for their relevance to other working researchers, to keep abreast with what’s new or exciting (or both)…
It was a Friday morning, and I had just emailed my department chair, along with the dean above him: “I will be sending my letter of resignation shortly, but you can take this as the informal notice.” Who, in their right mind, would give up a tenured job at the prestigious University of North Carolina…
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