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Cell culture has undoubtedly changed the face of biologic R&D over the past 30 years, and the vital role it plays has again been proven, this time allowing scientists from the Yale Cancer Center to discover a new class of proteins that inhibits HIV infection in cells.

The research was published recently in the Journal of Virology and the study’s lead author, Daniel DiMaio, thinks that it has implications for developing new strategies for the treatment and prevention of HIV and AIDS.

The team at Yale was able to isolate six 43- and 44-amino acid proteins that inhibited cell-surface and total expression of an essential HIV receptor and were able to block HIV infection in laboratory cell cultures.

The proteins were modeled on a protein from a bovine papillomavirus related to the human papillomavirus, which is one of the main causes of cervical cancer.

To learn more about the power and tools provided by cell culture, attend the Cell Culture World Congress USA in which leading bio-manufacturers and drug developers will discuss the role of cell culture processes and technologies in developing more effective biologic drugs and increasing efficiency for R&D.

View similar F1000 evaluations in HIV or read the original article or the YaleNews press release.