blog

For those of us in the Northern Hemisphere, spring has just sprung and nothing signifies this season more than spring chickens. The feathered fowl generated quite a few headlines in February after researchers from the Roslin Institute at the University of Edinburgh published a paper in Development about producing gene-edited chickens as a way of preserving rare breeds. In a nod to this work, we are highlighting the top 3 recommended articles in the area of gene editing in this month’s blog post as well as the usual top 3 articles for the month and Hidden Jewels.

F1000Prime is a literature recommendation service. The service has a peer-nominated global Faculty of more than 8,000 of the world’s leading biomedical scientists and clinicians who select those articles they think are particularly interesting and important, and write recommendations explaining their selection. From the numerical ratings awarded, we have created a unique system for quantifying the importance of individual articles.

Top 3 article recommendations about gene editing

“The authors show that by genome editing in Down Syndrome-patient-derived induced pluripotent stem cells it is possible to introduce the X-inactive specific transcript (XIST) gene.” – Benedikt Berninger, Johannes Gutenberg University Mainz

Translating dosage compensation to trisomy 21

Jiang J, Jing Y, Cost GJ, Chiang JC, Kolpa HJ, Cotton AM, Carone DM, Carone BR, Shivak DA,Guschin DY, Pearl JR, Rebar EJ, Byron M, Gregory PD, Brown CJ, Urnov FD, Hall LL, Lawrence JB. Nature. 2013 Aug 15; 500(7462):296-300

“An astonishing feature of the CRISPR/Cas9 engineering tool and one that distinguishes it from other genome targeting technologies is the possibility for multiplexed editing.” – Marlene Belfort and Olga Novikova, University at Albany, State University of New York

Hidden Jewels

Hidden Jewels rankings only include articles published in specialist journals, recommended in F1000Prime during the preceding 30 days.

“Notwithstanding the limitations in this study, the data serve to remind clinicians to be wary of PPI prescription, which may not be as harmless as previously imagined, and fuel further studies to investigate an underlying causative association.” – Sydney Tang and Gary Chan, The University of Hong Kong

Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease.

Lazarus B, Chen Y, Wilson FP, Sang Y, Chang AR, Coresh J, Grams ME.

JAMA Intern Med. 2016 Feb; 176(2):238-46

 

“This is a nice piece of work that should dispel myths about the lack of correlation between RNA and proteins, but which at the same time emphasizes the importance of proteomics research.” – Alvis Brazma, European Bioinformatics Institute

Gene-specific correlation of RNA and protein levels in human cells and tissues.

Edfors F, Danielsson F, Hallström BM, Käll L, Lundberg E, Pontén F, Forsström B, Uhlén M. J Clin Invest. 2016 Nov 01; 126(11):4119-4124.

“This work strengthens the importance of performing a deep and sustained MAPK signaling inhibition to make the radioiodide treatment more effective. Whether this strategy would also be beneficial in patients is something that remains to be elucidated.” – Pilar Santisteban and Garcilaso Riesco-Eizaguirre, Spanish National Research Council (CSIC)-Universidad Autónoma de Madrid

Sustained ERK inhibition maximizes responses of BrafV600E thyroid cancers to radioiodine.

Nagarajah J, Le M, Knauf JA, Ferrandino G, Montero-Conde C, Pillarsetty N, Bolaender A, Irwin C,Krishnamoorthy GP, Saqcena M, Larson SM, Ho AL, Seshan V, Ishii N, Carrasco N, Rosen N, Weber WA, Fagin JA. J Clin Invest. 2016 Nov 01; 126(11):4119-4124