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A selection of new content on F1000Research from the past week. To receive notification of all new articles, sign up for our table of contents alerts.

Featured article

Active transmembrane drug transport in microgravity: a validation study using an ABC transporter model [v1; ref status: indexed, https://f1000r.es/41n]
Sergi Vaquer, Elisabet Cuyàs, Arnau Rabadán, Albert González, Felip Fenollosa, Rafael de la Torre

“To test the effect of microgravity on ATP-Binding Cassette (ABC) transporters a Vesicular Transport Assay^® (Solvo Biotechnology, Hungary) was adapted to evaluate multi-drug resistance-associated protein 2 (MRP2) trans-membrane estradiol-17-β-glucuronide (E17βG) transport activity, when activated by adenosine-tri-phosphate (ATP) during parabolic flights. Simple diffusion, ATP-independent transport and benzbromarone inhibition were also evaluated. Results revealed significantly reduced MRP2 net transport activity in microgravity, as well as signal detected in simple diffusion samples. Ultra-structural changes induced by gravitational stress upon vesicle membranes or transporters could explain the current results, although alternative explanations are possible.”

Other newly indexed articles

Does the linear Sry transcript function as a ceRNA for miR-138? The sense of antisense [v2; ref status: indexed, https://f1000r.es/4pd]
Javier Tadeo Granados-Riveron, Guillermo Aquino-Jarquin

Working memory training shows immediate and long-term effects on cognitive performance in children [v2; ref status: indexed, https://f1000r.es/4rj]
Fiona Pugin, Andreas J. Metz, Madlaina Stauffer, Martin Wolf, Oskar G. Jenni, Reto Huber

Rice (Oryza) hemoglobins [v2; ref status: indexed, https://f1000r.es/4vp]
Raúl Arredondo-Peter, Jose F. Moran, Gautam Sarath

Characterization of the truncated hemoglobin THB1 from protein extracts of Chlamydomonas reinhardtii [v1; ref status: indexed, https://f1000r.es/4ub]
Eric A. Johnson, Juliette T.J. Lecomte