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A selection of new content on F1000Research from the past week. To receive notification of all new articles, sign up for our table of contents alerts.

Featured article

Plasmodium falciparum infection rates for some Anopheles spp. from Guinea-Bissau, West Africa [v1; ref status: indexed, https://f1000r.es/4in]

Michelle R. Sanford, Anthony J. Cornel, Catelyn C. Nieman, Joao Dinis, Clare D. Marsden, Allison M. Weakley, Sarah Han, Amabelia Rodrigues, Gregory C. Lanzaro, Yoosook Lee

Malaria is among the leading causes of childhood mortality in Guinea-Bissau, comprising 18% of mortality of children less than five years of age, as of 2010 and varies considerably from year to year with a general decrease in recent years to about 3 children (<5 yrs of age) per thousand in some locations. Presence of Plasmodium falciparum circumsporozoite protein (CSP) was detected by enzyme linked immunosorbent assay (ELISA) in a sample of Anopheles gambiae s.s., A. melas and A. pharoensis collected in Guinea-Bissau during October and November 2009. The percentage of P. falciparum infected samples was comparable to earlier studies from other sites in Guinea-Bissau. The majority of the specimens collected were identified as A. gambiae which had an individual infection rate of 12.6 % across collection sites. A small number of specimens of A. coluzzii, A. coluzzii x A. gambiae hybrids, A. melas and A. pharoensis were collected and had infection rates of 4.3%, 4.1%, 11.1% and 33.3% respectively. Despite being present in low numbers in indoor collections, the exophilic feeding behaviors of A. melas (N=18) and A. pharoensis (N=6) and high infection rates observed in this survey suggest falciparum-malaria transmission potential outside of the protection of bed nets.

Newly Indexed Articles

Late cardiac sodium current can be assessed using automated patch-clamp [v1; ref status: indexed, https://f1000r.es/4kj]

Morgan Chevalier, Bogdan Amuzescu, Vaibhavkumar Gawali, Hannes Todt, Thomas Knott, Olaf Scheel, Hugues Abriel

 

Secretomes of apoptotic mononuclear cells ameliorate neurological damage in rats with focal ischemia [v2; ref status: indexed, https://f1000r.es/4kv]

Patrick Altmann, Michael Mildner, Thomas Haider, Denise Traxler, Lucian Beer, Robin Ristl, Bahar Golabi, Christian Gabriel, Fritz Leutmezer, Hendrik Jan Ankersmit

 

Developing sustainable software solutions for bioinformatics by the “Butterfly” paradigm [v2; ref status: indexed, https://f1000r.es/40q]

Zeeshan Ahmed, Saman Zeeshan, Thomas Dandekar