blog

Featured article

Back to the drawing board: Re-thinking the role of GLI1 in pancreatic carcinogenesis [v1; ref status: indexed, https://f1000r.es/4du]

Tara Hogenson, Matthias Lauth, Marina Pasca diMagliano, Martin Fernandez-Zapico

The protein GLI1, is a well conserved transcriptional mediator of Hedgehog (HH) signaling, and regulates multiple cellular processes such as cell fate determination, tissue patterning, proliferation and transformation, which give this transcription factor a significant role in carcinogenesis if deregulated. Surprisingly, clinical trials targeting HH/GLI1 axis in advanced pancreatic ductal adenocarcinoma (PDAC) were unsuccessful, leaving investigators questioning the mechanism behind these failures. Recent evidence suggests the loss of transcription factor GLI1 in the later stages PDAC may actually accelerate disease. This indicates GLI1 may play a dual role in PDAC, acting as an oncogene in the early stages of disease and a tumor-suppressor in the late stages.

Newly indexed articles

Plasmodium falciparum infection rates for some Anopheles spp. from Guinea-Bissau, West Africa [v1; ref status: indexed, https://f1000r.es/4in]

Michelle R. Sanford, Anthony J. Cornel, Catelyn C. Nieman, Joao Dinis, Clare D. Marsden, Allison M. Weakley, Sarah Han, Amabelia Rodrigues, Gregory C. Lanzaro, Yoosook Lee

Immunohistochemical visualization of mouse interneuron subtypes [v1; ref status: indexed, https://f1000r.es/4em]

Simon Molgaard, Maj Ulrichsen, Simon Boggild, Marie-Louise Holm, Christian Vaegter, Jens Nyengaard, Simon Glerup

Back to the drawing board: Re-thinking the role of GLI1 in pancreatic carcinogenesis [v1; ref status: indexed, https://f1000r.es/4du]

Tara Hogenson, Matthias Lauth, Marina Pasca diMagliano, Martin Fernandez-Zapico