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The October issue of the open-access review journal F1000Prime Reports is now out, and for this month’s feature, we thought we’d put cardiac metabolism in the spotlight.

In “Rethinking cardiac metabolism: metabolic cycles to refuel and rebuild the failing heart“, renowned expert in cardiovascular medicine, and F1000 Faculty Member for Intergrative Physiology Heinrich Taegtmeyer and co-author Genna Lubrano take a look at the heart from a ‘new conceptual framework’ – that of a continuously renewing, dynamic structure, converting chemical to mechanical energy whilst re-synthesizing the proteins that form itself.

With this view of the heart, as a self-renewing, energy converting ‘biological pump’, the authors look at the case of heart failure and how the presence or absence of the high-energy metabolites that act as the chemical ‘fuel’ for the heart will affect the degradation and re-synthesis of the muscles that keep us all alive.

All 12 of October’s F1000Prime Reports are now published and freely available below:

 
Regulating dynamin dynamics during endocytosis.

 
 

 
Reaching a consensus on the mechanism of dynamin?

 

 
Natural killer cell regulation – beyond the receptors.

 
 

 
Control systems and coordination protocols of the secretory pathway.

 
 

 
Advances in the diagnosis and treatment of sarcoidosis.

 

 
Rethinking cardiac metabolism: metabolic cycles to refuel and rebuild the failing heart.

 

 
Mechanical circulatory support in acute cardiogenic shock.

 
 

 
Transcatheter aortic valve implantation.

 
 

 
Expanding use of new oral anticoagulants.

 
 

 
Management of allergic rhinitis.

 
 

 
Future therapy of portal hypertension in liver cirrhosis – a guess.

 

 
Advances in treating acute myeloid leukemia.

 
 

The entire back catalog of F1000Prime Reports can be accessed here.