blog

Mariann Bienz is a Group Leader at the MRC Laboratory of Molecular Biology, Cambridge, as well as a member of the Developmental Molecular Mechanisms section at F1000Prime.

Here, Dr Bienz describes her research into the enigmatic, yet fundamental, mechanisms of Wnt signalling: a major cancer pathway. Dr Bienz and her colleagues lab were behind the discovery of the Pygo-Bcl9 complex over a decade ago (the paper on which was recommended at the time on F1000Prime), through genetic studies in flies. This complex has been shown to be a key component of these pathways and highly conserved in all animals.

Michael McDermott is Professor of Experimental Rheumatology at the Leeds Institute for Molecular Medicine, as well as a Faculty Member in the Rheumatology and Clinical Immunology Faculty of F1000Prime.

In this video, Professor McDermott talks to us about his main research interest: monogenic autoinflammation and its associated diseases. Since the coining of the term in 1999 (in a paper on which Professor McDermott was an author) the spectrum of autoinflammatory diseases has grown enormously, and now comprises conditions such as Behçet’s disease, Crohn’s and ankylosing spondylitis. As well as recommending articles on F1000Prime, Professor McDermott has written the review article ‘Periodic fever syndrome and autoinflammatory diseases‘ for our open-access journal F1000Prime Reports.