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John Cambier, member of the F1000 Immunology Faculty, recently met our Editorial Director in Biology, Kathleen Wets, at the National Jewish Medical and Research Center in Denver. In this video, he summarises his research interests in the area of immune signaling, particularly in B cells.

His lab has been studying the B cell antigen receptor (BCR) since the 1970s and was involved in the initial characterization of the BCR signaling pathways. This led to an interest in the regulation of BCR signaling, in particular the mechanisms behind anergy in B cells, e.g. in type 1 diabetics.

In addition, Cambier’s lab is interested in the effects of aging on B cells and how virus infection of an organism leads to a long period of immune unresponsiveness in B cells.

His latest evaluation for F1000 highlights a related paper suggesting that carriers of the PTPN22 risk allele have intrinsic defects in B cell tolerance, which predisposes them to the development of autoimmune disease.

Read more of Cambier’s evaluations.