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Determining the structures of neurotransmitter transporters is not only technically difficult (integral membrane proteins are notoriously recalcitrant subjects), but also the subject of much controversy. Knowledge of structure is essential to understanding mechanism, which can of course lead to more rational therapeutic design. Neurotransmitter transporters are important for the re-uptake of neurotransmitters after synapse firing: the serotonin transporter for example is the target for fluoxetine (Prozac), and stimulants such as cocaine and MDMA (ecstasy) act through these molecules.

F1000 Member Gary Rudnick is interested in structure and function of the serotonin transporter, regulation of its activity and what can be learned from studying bacterial homologues of the neurotransmitter transporter family. In this video he talks about his lab’s work and the usefulness of F1000 for discussing fast-moving fields:

…a nice venue for airing some of these differences

The controversial papers he mentions are evaluated here and the blog post is How many leucines?. Don’t forget that registered users can join in the debate on F1000.