A perfect storm

I’ve been following the developing story of NDM-1, an enzyme that confers antibiotic resistance to gram-negative bacteria, since before the first article on its appearance was published in The Lancet Infectious Diseases in August last year (see F1000 evaluations). At the time, many of the cases of infection in India – but not all –…

Discovering HIV

On Monday we reported on a trial showing that early retroviral treatment can protect partners of HIV-infected individuals. The findings are so good that the data were released early by the interim review board. This must put a smile on the face of Anthony Fauci, who has made great contributions to understanding how HIV destroys…

Long live scientists!

The BBC reports that life expectancy is on the rise in the UK–despite all those pies, chips and beer. It cites a paper by David Leon of the London School of hygiene and Tropical Medicine in the International Journal of Epidemiology, Trends in European life expectancy: a salutary view (open access: 10.1093/ije/dyr061). While I’m not…

Sick apes

Critical differences between the human immune system and that of other primates, such as chimpanzees and rhesus macaques, lead to humans being more susceptible to a number of infectious agents including HIV and malaria. Now, the first genome-wide functional comparison in chimps, macaques and humans reveals changes in immune system gene expression that could explain…