Thirty years since the announcement of HIV as the cause of AIDS

Since the first reports of AIDS, approximately 36 million people have died from the disease, with an estimated 35 million living with HIV. Drug therapy consists of HAART, highly active antiretroviral therapy, which slows progression of the disease and lessens risk of death. Today, researchers are closer than ever to finding a functional cure and developing a preventive vaccine; however, research could not have begun without an event that took place thirty years ago today.

HIV-1 VirusAIDS was first recognized by the US CDC in 1981, but it was to be a few more years before its cause was discovered. On April 23rd 1984, Dr Robert C Gallo and colleagues announced this very discovery – they had identified the retrovirus that causes AIDS, but, more importantly, they had also developed an HIV blood test in order to diagnose the illness.
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Focusing on reference management at F1000’s London office

We’d like to invite you to an evening at F1000’s London office on Tuesday May 6th to preview the latest F1000 technology under development, specifically focused on writing and organizing research papers. Your views will help us shape these products.


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The event will commence with a presentation from CEO Daniel Marovitz followed by discussions in small break-out groups led by F1000 product specialists. There will be time for networking over refreshments, and as an added ‘thank you’, all attendees will receive a £25 Amazon voucher. The event will last approximately two hours.
So if you’re a scientist or clinician – in training or in practice – and in the area next month, we hope you can join us. See below to sign up for our focus group; spaces are limited so please sign up soon to secure your place.

Event: F1000 reference management focus group
When: Tuesday 6th May, 6pm onwards
Where: Science Navigation Group, 3rd Floor, Middlesex House, 34-42 Cleveland Street, W1T 4LB
How: Sign up for a free ticket

If you’re not able to attend the event, but are interested in contributing to our reference management focus group in other ways, please contact us.

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Easter F1000 Twitter round up

A round-up of the most popular tweets on @F1000 this week, as well as other choice picks from the Twittersphere.

On behalf of the F1000Prime team, we’d like to wish you all a happy Easter!

Easter cakes, provided for the team's delectation by Joanna Rozmus.

Easter cakes, provided for the team’s delectation by Joanna Rozmus.

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Announcing a plethora of F1000Prime award winners

We are delighted, once again, to be able to announce the winners of our annual ‘Faculty Member of the Year’ and ‘Associate Faculty Member Travel Grant’ awards. In addition, we’re thrilled to unveil a completely new award – Outstanding Faculty Member of 2013.

These awards recognize the hard work of our Faculty Members and Associate Faculty Members, of whom there are over 10,000. In 2013, we received a whopping 16,654 submissions – the highest yearly total to date – contributing to over 152,000 recommendations of 117,000+ articles. This would not have been possible without the dedication of our Faculty, who provide insightful recommendations of articles that impact their research. We applaud your efforts. Continue reading

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Video tips: Get familiar with your F1000Prime homepage

This is the first in a short series of video demonstrations of major features of F1000Prime. If you can’t wait for the next blog post, take a look at all our recorded demonstrations and webinars on the F1000 YouTube channel.

Setting up your F1000Prime homepage
F1000Prime can save you even more time in your reading and literature searching if you create a personalized homepage and email alert. The short set-up process starts by entering at least three keywords describing your research interests. The key words can be broad or specific – it doesn’t matter; just describe your interests in your own way and the technology behind F1000Prime suggests a few of approximately 300 total sections across biology and medicine that are likely to be relevant to your interests. The keywords and sections can always be amended.

Once registered or signed in to F1000Prime, you can see your personalized homepage and also receive an email alert – like a personalized table of contents across all of PubMed – with new content on your homepage.

Key features of your F1000Prime homepage
The left-hand article feed on your F1000Prime homepage consists of articles recommended in F1000Prime matched to your research interests. You can see the Faculty Member who most recently recommended the article and a preview of their recommendation comment.

The feed on the right-hand side includes articles matched to your research interests from all of PubMed. If you notice any irrelevant articles in your PubMed feed, use the ‘not relevant’ button to train the system. The more you use F1000Prime the more accurate the personalized articles recommendations will become.

You can save/follow articles in F1000Prime and PubMed, to be alerted to new recommendations of, and comments on, any article. All saved and followed articles are accessible from MyF1000 and in F1000Journal Clubs. You can, also, nominate an article indexed in PubMed for inclusion in F1000Prime if you feel it’s particularly important.

Your homepage also provides a list of Faculty Members you ‘follow’ and a list of recommended Faculty Members you might want to follow. Because we’re increasingly learning about our users’ research interests, we match these to the research interests of our Faculty Members – which we know a lot about already. Following a Faculty Member means you’ll be alerted to new recommendations or dissenting opinions they publish and any comments they make on other article recommendations. Your personal homepage also includes potentially relevant articles from our open access journal F1000Prime Reports. These articles provide commentary on the latest important advances across entire sections of F1000Prime.

In the next video and blog, we’ll be covering our intelligent SmartSearch feature.

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Cytokines, stomachs and primordial soup

A round-up of the week's most popular tweets on @F1000 , as well as some other interesting picks from the rest of Twitter...

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Stephen Udem

Steve
It is with great sadness that we note the death of Pharmacology & Drug Discovery Faculty Member Stephen A. Udem.

Stephen joined F1000Prime in 2010. A native New Yorker, he was a student at the Albert Einstein College of Medicine, where he became a professor 25 years later, and he also held positions at the New Jersey Medical School over the course of his career. He was an esteemed virologist and vaccinologist, and his work focused on RNA viruses, specifically those causing human respiratory diseases. His achievements were extensive: he held many patents, has published over 80 papers, and contributed much to the design and development of vaccines, one of which is currently undergoing testing in clinical trials.

An obituary has been published by The New York Times, and you can read more about Stephen and his outstanding medical career on his website.

We extend our deepest sympathies to his friends and family.

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F1000Prime most influential: Oncology

While more than 18,000 cancer researchers are gathered in San Diego for the American Association for Cancer Research (AACR) meeting this week, we’re highlighting the most influential research articles in oncology in 2013 and a prestigious award for one of our Heads of Faculty.

Prof. Bob Pinedo, Professor of Medical Oncology, Free University (VUMC) Amsterdam, and Head of Faculty for Oncology said on reviewing the list: “Oncology is a large field with thousands of articles published every month across hundreds of journals, making the need for effective filtering and critical evaluation tools even more acute. This is especially true in clinical oncology, with many small and early phase trials happening at one time, making the Hidden Jewels feature of F1000Prime particularly valuable. Important clinical advances were seen in 2013 in various leukemia types, lung cancer, breast cancer and others, which may be reflected in the clinical nature of these “most influential” articles identified by F1000 Faculty Members in Oncology.”

Bob Pinedo was in March awarded the 2014 David A. Karnofsky Memorial Award for his crucial contributions towards the biology of cancer and the early detection of the disease. Partly because of Pinedo’s work, a number of forms of cancer have become treatable with medication.

By James Grellier – derivative of original work by VashiDonsk at en.wikipedia [CC-BY-SA-3.0 (http://creativecommons.org/licenses/by-sa/3.0)], via Wikimedia Commons

In 2013, the highest scoring article in oncology in F1000Prime describes the identification, for the first time, of a stem cell niche in mouse ovaries. The findings may help in the development of diagnostic tools for ovarian cancer – the fifth leading cause of cancer deaths in the US.

The leading article in a specialist journal in oncology is a randomized controlled trial that compared two non-surgical treatments – creams – for skin cancer with photodynamic therapy, in an area where head-to-head comparisons of treatments are rare.

Every article recommendation in this Top 10 is free to read from the links in this blog.

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Science in the media and the stem cell acid trip

Here are this week's most popular tweets on the @F1000 feed, as well as some other interesting picks from the rest of Twitter...

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Are we all done with citations?

The most comprehensive analysis to date finds that F1000Prime-recommended articles receive more citations compared to other articles, and that a higher F1000Prime score is associated with higher numbers of citations. Assuming these findings stand the test of peer review, now is the time to focus on new questions about how we assess the impact and quality of research with F1000Prime ratings – and other metrics.

Dr Lutz Bornmann’s article – deposited this week in arXiv – primarily investigates “convergent validity” (whether F1000Prime recommendations correlate with citation impact) and the consistency of the ratings and tags of the same article assigned by Faculty Members (“inter-rater reliability”). Bornmann, in this study, analyzed recommendations of around 100,000 articles (the majority of the F1000Prime database as of January 2014).

By futureatlas.com (originally posted to Flickr as “Citation needed”) [CC-BY-2.0 (http://creativecommons.org/licenses/by/2.0)], via Wikimedia Commons

As well as agreeing with previous studies on the correlation between F1000Prime recommendations and citations, Bornmann, of the Max Planck Society, combines these results in a meta-analysis providing a more definitive answer. And finds, “the proportion of highly cited papers among those selected by the Faculty Members is significantly higher than expected.” The results also show an increasing – and statistically significant, due to the large sample size – likelihood of an article being highly cited when it is awarded 1 (40%), 2 (60%) or 3 (73% stars).

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